Psychotropic drugs interaction with the lipid nanoparticle of COVID-19 mRNA therapeutics
2.5 Potential interference with psychotropic drugs
Several psychotropic drugs, including clozapine, olanzapine, haloperidol, and imipramine, were shown to up-regulate ApoE, a cholesterol transporter disrupted in SPI, suggesting possible interference with LNP transfection (Barroso et al., 2015; Dean et al., 2003; Digney et al., 2005; Miatmoko et al., 2021; Vik-Mo et al., 2009). As psychotropic medications upregulate the ATP-binding cassette transporter A1 (ABCA1), increasing cholesterol egress from cells, a process that may compromise vaccine efficacy by flushing LNPs into the extracellular compartment prior to mRNA release (Luquain-Costaz et al., 2020). In addition, several psychotropic drugs, including aripiprazole, haloperidol, and trazodone, were reported to increase the levels of cholesterol precursor, desmosterol, that in turn upregulates the expression of cholesterol efflux genes, likely removing LNPs from cells prematurely (Korade et al., 2017).
https://pmc.ncbi.nlm.nih.gov/articles/PMC9503827/